冠心病患者血清可溶性细胞间黏附分子-1和P选择素的变化

目的 ]探讨血清可溶性细胞间黏附分子 - 1(sICAM - 1)和P选择素 (sP -selectin)水平与冠心病活动性间的关系。 方法 ]用ELISA法测定 19例稳定型心绞痛 (SAP)、18例不稳定型心绞痛 (UAP)、13例急性心肌梗塞 (AMI)患者血清sICAM - 1和sP -selectin浓度 ,进行统计学分析。结果 ]AMI组血清sICAM - 1、sP -selectin浓度高于UAP组 ,UAP组血清sICAM - 1、sP -se lectin浓度高于SAP组 (sICAM - 1在 3组中比较P值均 <0 .0 0 1;sP -selectin在AMI组与SA组P <0 .0 0 1,UA组与SA组比较P =0 .0 3,AMI组与UA组P =0 .0 2 ,均有显著性差异 )。方差分析表明 ,血清sICAM - 1及sP -selectin浓度均与冠心病的活动性呈现正相关。 结论 ]sICAM - 1、sP -selectin浓度与冠心病的活动性有关。

Changes of serum soluble intercellular adhesion molecule-1 and P-selectin in coronary heart disease

Objectives] To investigate the relation between the changes of serum soluble intercellular adhesion molecule -1(sICAM-1);P-selectin (sP-selectin)and the activity of coronary heart disease(CHD). Methods] The concentrations of serum sICAM-1 and sP-selectin were evaluated by means of enzyme linked immunosorbant assay (ELISA) in 19 patients of stable angina pectoris(SAP),18 patients of unstable angina pectoris(UAP), and 13 patients of acute myocardial infarction(AMI). Results] The concentrations of serum sICAM-1 and sP-selectin were higher in AMI than those in UAP, and significantly higher than those in SAP(sICAM-1 :P<0.001;sP-selectin:SAPvsUAP P=0.03,SAPvsAMI P<0.001,UAPvsAMI P=0.02) Conclusion] The concentrations of serum sICAM-1 and sP-selectin were correlated with the activity of CHD.