血浆瘦素与体重指数和脂肪分布的关系

目的探讨血浆瘦素水平与体重指数和脂肪分布的关系。方法对100例肥胖者(男性52例,女性48例)和71非肥胖者(男性38例,女性33例)用免疫放射法测定血浆瘦素水平,测量身高、体重,计算体重指数(BMI)。对其中19例肥胖者(男12例,女7例),15例非肥胖者(男6例,女9例)经CT扫描测量腹部内脏和皮下脂肪面积,分析瘦素与肥胖程度和脂肪分布的关系。结果血浆瘦素水平性别差异显著(P<0.001),女性是男性的2～3倍;瘦素与体重指数呈正相关(男r=0.6772,P<0.01;女r=0.7191,P<0.01)。经CT扫描测量皮下和内脏脂肪面积,瘦素水平与皮下脂肪面积的正相关(r=0.8238,P<0.01),与腹部内脏脂肪面积无明显相关性(r=0.2118,P>0.05)。结论肥胖者血浆瘦素升高,瘦素水平不仅与肥胖程度有关,还与脂肪分布有关。

The relationship between plasma leptin levels and body mass index as well as fat distribution

Objective To investigate the relationship between human plasma leptin concentrations and body mass index as well as fat distribution in obesity.Methods We measured plasma leptin concentrations with IRMA of 100 obese (including 52 men and 48 women) and 71 non-obese (including 38 men and 33 women).Height,body weight were measured to calculate body mass index (BMI).We used CT to evaluate subcutaneous and intra-abdominal fat area of 19 normal weight persons (including 12 men and 7 women) and 15 obese (including 6 men and 9 women).Results Plasma leptin levels are 2-3 times in female than in male,the difference is significantly(P<0.001).Leptin values are correlated with BMI(r=0.6772,P<0.01 in male and r=0.7191,P<0.01 in female).Leptin levels are correlated with subcutaneous fat areas(r=0.8238,P<0.01),and not correlated with intra-abdominal fat areas(r= 0.2118,P>0.05).Conclusion Leptin levels are higher in obese subjects than that in non-obese ones. Leptin levels are associated with fat content and fat distribution.