| 阿西美辛海藻酸钙凝胶微丸释药影响因素考察 |
| |
| 引用本文： | 张良珂,张彦,田睿,赖洁娟. 阿西美辛海藻酸钙凝胶微丸释药影响因素考察[J]. 中国医院药学杂志, 2007, 27(12): 1671-1674 |
| |
| 作者姓名： | 张良珂 张彦 田睿 赖洁娟 |
| |
| 作者单位： | 1. 重庆医科大学药学院,重庆,400016
2. 重庆药友制药有限责任公司,重庆,401121 |
| |
| 摘 要： | 目的:考察阿西美辛海藻酸钙凝胶微丸的释药机制。方法:采用滴制法制备阿西美辛海藻酸钙微丸,考察海藻酸钠浓度,钙离子浓度,投药量,滴头直径大小对药物释放的影响。结果:海藻酸钠浓度增加,钙离子浓度增加,滴头直径增加,释药速率减慢。结论:在体外释放度实验中,阿西美辛海藻酸钙凝胶微丸具有良好的缓释作用,海藻酸钙凝胶微丸是一种非常有潜力的药物载体。
|
| 关 键 词： | 阿西美辛 海藻酸钙 凝胶微丸 缓释制剂 |
| 文章编号： | 1001-5213（2007）12-1671-04 |
| 收稿时间： | 2006-11-03 |
| 修稿时间： | 2006-11-03 |
Study on the release properties of acemetacin calcium alginate gel beads |
| |
| ZHANG Liang-ke,ZHANG Yan,TIAN Rui,LAI Jie-juan. Study on the release properties of acemetacin calcium alginate gel beads[J]. Chinese Journal of Hospital Pharmacy, 2007, 27(12): 1671-1674 |
| |
| Authors: | ZHANG Liang-ke ZHANG Yan TIAN Rui LAI Jie-juan |
| |
| Abstract: | OBJECTIVE To investigate the release properties of acemetacin calcium alginate gel beads.METHODS Acemetacin calcium alginate gel beads were prepared by the dropping method.The effects of several factors such as the concentration of sodium alginate and calcium ion,drug loading,inner diameter of needle on drug release properties were investigated respectively.RESULTS Increasing the concentration of sodium alginate or calcium ion,the inner diameter of needle,the rate of drug release decreased.CONCLUSION Alginate gel beads shows good sustained-release properties. |
| |
| Keywords: | Acemetacin Calcium alginate gel beads sustained-release |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
