| 广东汉族人纤溶酶原激活剂抑制物-1基因4G／5G多态性与2型糖尿病肾病的相关性 |
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| 摘 要： |
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| 关 键 词： | 纤溶酶原激活剂抑制物-1 基因型 等位基因频率 遗传多态性 2型糖尿病肾病 |
Relationship between plasminogen activator inhibitor-1 gene 4G/5G polymorphism and type 2 diabetic nephropathy in Chinese Han patients in Guangdong Province] |
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| Authors: | Shi-qun Liu Yao-ming Xue Guang-cai Yang Fei-ying He Xiao-shan Zhao |
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| Institution: | Department of Endocrinology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. |
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| Abstract: | OBJECTIVE: To understand the association between plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G polymorphism and type 2 diabetic nephropathy (DN) in Chinese Han patients in Guangdong Province. METHODS: PAI-1 gene 4G/5G polymorphism was analyzed in 26 normal individuals, 77 patients with type 2 diabetic nephropathy and 70 type 2 diabetic patients without nephropathy (DNN) by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The 4G/4G genotype frequencies of PAI-1 gene were higher in DN than in DNN patients (0.390 vs 0.171, chi(2)=13.008, P<0.01), with the odds ratio (OR) of 1.447 (95% confidence interval: 0.533-3.934, P<0.05) in comparison with 5G/5G genotypes between the 2 patient groups. The 4G allele frequencies of PAI-1 gene were similar in DN and DNN groups (0.57 vs 0.51, chi(2)=1.22, P>0.05). CONCLUSION: The PAI-1 4G/4G genotype is associated with increased risk for type 2 DN the Chinese Han population in Guangdong Province, and type 2 diabetic patients with 4G/4G PAI-1 genotype are more likely to develop DN than those with 5G/5G PAI-1 genotype. |
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