葛根素注射液与复方丹参注射液治疗不稳定型心绞痛的疗效比较

目的比较葛根素注射液与复方丹参注射液治疗不稳定型心绞痛的疗效。方法98例不稳定型心绞痛患者随机分为治疗组50例和对照组48例。两组患者均常规口服缓释硝酸异山梨酯（消心痛）、肠溶阿司匹林及硝苯地平。心绞痛发作时舌下含服硝酸甘油。治疗组加用葛根素注射液10 mL，对照组加用复方丹参注射液40 mL，加入5%葡萄糖注射液500 mL，静脉滴注，qd。两组均连续应用14 d。观察临床症状、心电图变化及血液流变学变化指标。结果治疗组与对照组临床疗效总有效率分别为96.0%及81.2%，差异有显著性（P＜0.05）；治疗组在治疗后低切全血黏度明显降低（P＜0.05），红细胞变形性显著增高，红细胞比容、红细胞聚集指数和血小板聚集率均显著下降，治疗前后比较差异有极显著性（P＜0.01）。对低切全血黏度的下降和红细胞变形性升高幅度，治疗组显著高于对照组（P＜0.01）。对红细胞比容，红细胞聚集指数和血小板聚集率的下降作用，治疗组优于对照组（P＜0.05）。结论葛根素注射液治疗不稳定型心绞痛疗效优于复方丹参注射液。

A Comparison between the Therapeutic Effects of Puerarin Injection and Compound Radix Salviae Miltiorrhizae Injection in the Treatment of Unstable Angina Pectoris

Objective To compare the therapeutic effects of puerarin injection and compound Radix Salviae Miltiorrhizae injection in the treatment of unstable angina pectoris(UAP). Methods Ninety-eight patients with unstable angina pectoris were randomly divided into two groups: the trial group(n=50) and control group(n=48).Patients of both group were treated routinely with isosorbide dinitrate,enteric-soluble aspirin and nifedipine.Nitroglycerin to be sucked sublingually were administered during episodes of angina pectoris.On the basis of these conventional measures,patients of the trial group were given each 10 mL of puerarin injection added to 500 mL of 5%glucose solution administered by IV instillation q.d.,while those of the control group were given each 40 mL of compound Radix Salviae Miltiorrhizae injection added to 500 mL of 5%glucose solution administered by IV instillation q.d.as well.The course of treatment in both groups lasted 14 days.Clinical symptoms,changes in electrocardiogram and parameters of hemorrheology were kept under observation before and after the treatment. Results The overall effective rates in patients of the trial group and control group were 96.0% and 81.2%,respectively,the difference being significant(P<0.05).The low shear value of the whole blood viscosity was sharply decreased(P<0.05),the erythrocyte deformability was apparently increased,while the hematocrit,erythrocyte aggregation index and platelet aggregation rate were markedly decreased in patients of the trial group.Differences between these parameters before and after the treatment in patients of the trial group were significant(P<0.01).Changes in these parameters after the treatment were much more pronounced in patients of the trial group than in those of the control group(P<0.01 or P<0.05). Conclusion Puerarin injection was shown to be superior to compound Radix Salviae Miltiorrhizae injection in the treatment of unstable angina pectoris.