Analysis of oocyte cryopreservation in assisted reproduction: the Italian National Register data from 2005 to 2007 |
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| Authors: | G Scaravelli V Vigiliano JM Mayorga S Bolli R De Luca P D’Aloja |
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| Institution: | 1. Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland;2. Dana Center for Preventive Ophthalmology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland;3. Division of Health Sciences Informatics, Johns Hopkins University School of Medicine, Baltimore, Maryland;1. Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao, 266100, China;2. College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao, 266100, China;1. Graduate School of Environmental Science, Hokkaido University, Kita 10 Nishi 5, Sapporo 060-0810, Japan;2. Department of Fisheries and Centre for Environment and Science Education (CESE), Lagos State University, Ojo, Lagos, Nigeria;3. Graduate School of Fisheries Sciences, Hokkaido University, Hakodate 041-8611, Japan;1. College of the Environment and Ecology, Xiamen University, Xiamen, 361102, PR China;2. College of Ocean and Earth Sciences, Xiamen University, Xiamen, 361102, PR China;1. Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai 200444, PR China;2. Shanghai Key Laboratory of Bio-Energy Crops, Shanghai University, Shanghai 200444, PR China;3. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210036, PR China |
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| Abstract: | This paper reports on oocyte cryopreservation efficacy in Italy with respect to successful IVF from 2005 to 2007, presenting data from 193 centres collected by the Italian National Register. Post-thawing survival rates, number of transferred embryos, implantation rates and clinical pregnancy rates per transfer with respect to frozen/vitrified oocytes (FVO) were analysed. These numbers were compared with those obtained using frozen embryos or fresh oocytes. A total of 121,708 cycles were initiated, of which, 7.1% (8682) were FVO cycles and 2.4% (2952) were frozen embryo cycles. Of the 81,786 FVO, 52.5% (42,917) were thawed and 26.9% (22,005) inseminated. Of those inseminated, 68.0% (14,966) yielded good embryos. These numbers were significantly lower than those using fresh oocytes in which 77.9% (197,242; fresh oocytes versus FVO P < 0.001) of inseminated oocytes generated good embryos. Implantation rate using FVO was 6.9%, which was significantly lower than that using fresh oocytes (13.5%; P < 0.001) and frozen embryos (8.8%; P < 0.001). Pregnancy rate per transfer using FVO was 12.5% and significantly lower than that using fresh oocytes (24.9%; P < 0.001) or frozen embryos (16.4%; P < 0.001). There were 505 deliveries after IVF with FVO and 582 babies. |
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