角膜胶原交联技术的临床应用

目的:观察角膜胶原交联技术(CXL)的临床应用及治疗效果。方法:回顾性分析郑州市第二人民医院2019年1至6月行CXL或屈光手术联合CXL者62例(84只眼)的临床资料。其中圆锥角膜42例(46只眼)，采用核黄素及紫外线诱导的快速去上皮CXL；薄角膜及高度近视20例(38只眼)，进行角膜屈光手术联合CXL。术后随访12...

Clinical application of corneal collagen cross-linking technology

Objective To observe the clinical application and the treatment efficacy of corneal collagen cross-linking(CXL)technology.Methods The clinical data of 84 eyes of 62 patients who underwent CXL or CXL combined refractive surgery from Jan.to Jun.2019 in Zhengzhou Municipal Second People’s Hospital were analyzed retrospectively.Amongst all of them,there were 46 eyes of 42 cases of keratoconus who underwent riboflavin/UVA-induced rapid epithelial CXL,and 38 eyes of 20 cases with thin cornea,high myopia and astigmatism were treated with femosecond laser in situ keratomileusis combined with CXL(FS-CXL).The patients were followed-up for 12 months after surgery.The complications were observed and symptomatic treatment was performed for the patients.Results At 12-month after-CXL,ucorrected visual acuity(UCVA)were improved from 0.95±0.36 to 0.82±0.33 and BCVA improved from 0.43±0.21 to 0.31±0.22 respectively(t=8.668,8.471;all P<0.05).The corneal topographic measurements revealed the maximum curvature of anterior corneal surface decreased by(2.65±2.49)D.The difference was statistically significant(t=7.178,P<0.05).FS-CXL:The safety index(postoperative BCVA/preoperative BCVA)were 1.05±0.03,and the validity index(postoperative UCVA/preoperative BCVA)were 1.01±0.02.Among 46 eyes of keratoconus,4 eyes had high intraocular pressure,2 eyes had delayed corneal epithelial healing,1 case had limbal corneal infiltration,and 1 case had a decrease in corneal endothelial cell density after CXL.In 38 eyes of combined operation,1 case of marginal immune corneal inflammation and 1 case of short-term keratoconus changes occurred.All complications were cured or alleviated after symptomatic treatment.Conclusion Corneal cross-linking is the first choice for the treatment of advanced keratoconus.CXL combined with corneal refractive surgery therapy is effective for the treatment of thin cornea and high myopia.