Features and clinical implications of hepatitis B virus genotypes and mutations in basal core promoter/precore region in 507 Chinese patients with acute and chronic hepatitis B |
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| Authors: | Yan Liu Yanwei Zhong Zhengsheng Zou Zhihui Xu Baosen Li Xiaoqiang Ren Siyu Bai Lin Wang Xiaodong Li Jiuzeng Dai Yao Wang Panyong Mao Dongping Xu |
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| Affiliation: | 1. Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Research Center for Reproductive Medicine, Shantou University Medical College, Shantou 515041, China;2. Jinxin Research Institute for Reproductive Medicine and Genetics, Chengdu Jinjiang Hospital for Maternal and Child Health Care, Chengdu 610000, China;3. Faculty of Science and Engineering, University Paul Sabatier, Toulouse 31062, France;4. Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing 400020, China;1. Department of Epidemiology, Second Military Medical University, Shanghai;2. Department of Microbiology, School of Basic Medical Science, Peking University Health Science Center, Beijing;3. Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Institute/Hospital, Second Military Medical University, Shanghai;4. Division of Chronic Diseases, Center for Disease Control and Prevention of Yangpu District, Shanghai;5. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing;6. International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute/Hospital, Second Military Medical University, Shanghai, China |
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| Abstract: | BackgroundThe association of hepatitis B virus (HBV) genotypes and basal core promoter (BCP) and precore (PC) mutations with the clinical characteristics is increasingly recognized.ObjectiveTo investigate virologic features and clinical implications of HBV genotypes, BCP and PC mutations between large-size patients with acute hepatitis B (AHB) and chronic hepatitis B (CHB).Study designOne hundred and eighty-two AHB patients and 325 CHB patients were investigated. HBV genotypes and BCP/PC mutations were determined by direct sequencing. Mutations at 10 interested sites of the BCP/PC region were compared between the two groups of patients.ResultsAHB patients had a significantly higher ratio of genotype B to C than CHB patients (37.4–62.6% vs. 16.6–83.4%, P < 0.001). The prevalence of BCP/PC wild-type virus was 60.4% in AHB patients in contrast to 28.9% in CHB patients. Significantly lower prevalence of A1762T, G1764A, G1896A, and G1899A but higher prevalence of T1758C was found in AHB patients. Interestingly, T1758C and A1762T/G1764A appeared mutual restraint. Genotype B virus had lower BCP mutation frequency and similar PC mutation frequency compared to genotype C virus. AHB patients with BCP/PC mutant virus had higher viral load, whereas CHB patients with BCP/PC mutant virus had lower viral load and elevated alanine aminotransferase, in comparison with those with the wild-type virus.ConclusionPatients with genotype B virus, BCP/PC wild-type virus or T1758C mutant virus were more susceptible to develop AHB, whereas high prevalence of the BCP/PC mutations was associated with CHB development. |
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