Factors associated with persistence of arthralgia among chikungunya virus-infected travellers: Report of 42 French cases |
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| Authors: | Sophie Larrieu Nicolas Pouderoux Thierry Pistone Laurent Filleul Marie-Catherine Receveur Daouda Sissoko Khaled Ezzedine Denis Malvy |
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| Affiliation: | 1. Cellule Interrégionale d’Épidémiologie d’Aquitaine, Bordeaux, France;2. Centre Hospitalier Universitaire de Bordeaux, France;3. Cellule Interrégionale d’Épidémiologie de la Réunion et Mayotte, La Réunion, France;1. Department of Pathology and Laboratory Medicine, Hospital Internacional, Barquisimeto, Venezuela;2. The Laboratory of Biochemistry, Instituto de Biomedicina, Caracas, Venezuela;1. 97410 Saint-Pierre, Reunion;2. Inserm CIC 1410, CHU de La Réunion, 97448 Saint-Pierre cedex, Reunion;3. 97460 Saint-Paul, Reunion;4. 97400 Saint-Denis, Reunion;5. Department of Bacteriology, Parasitology & Virology, CHR, Reunion;6. Department of Infectious and Tropical Diseases, Laveran Military Training Hospital, 13013 Marseille, France;7. Department of Rheumatology, Roger-Salengro Hospital, University of Lille 2, avenue du Professeur-Emile-Laine, 59047 Lille cedex, France;1. Animal, Dairy and Veterinary Sciences Department, Utah State University, Logan, UT 84335, United States;2. Institute for Antiviral Research, Utah State University, Logan, UT 84335, United States;3. Utah Veterinary Diagnostic Laboratory, Utah State University, Logan, UT 84335, United States;4. Defyrus, Inc., 2 Bloor Street W, Suite 2602, Toronto, ON M4W 3E2, Canada;1. Servicio de Dermatología, Hospital Universitari GermansTrias i Pujol, Universitat Autònoma de Barcelona, Badalona, España;2. Servicio de Dermatología, Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, España;1. Athletic Training and Sports Medicine Research Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania, U.S.A.;2. Penn State Hershey Bone and Joint Institute, State College, State College, Pennsylvania, U.S.A.;1. Hepatitis Group, National Institute of Virology, Pune, 130/1, Sus Road, Pashan, Pune, Maharashtra 411021 India;2. Sanjeevan Hospital, Latur, Maharashtra, India |
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| Abstract: | BackgroundIn 2005–2006, a major epidemic of CHIKV infection occurred in the Islands of the south-western Indian Ocean, and longstanding manifestations seemed to be more frequent than described before.ObjectivesTo describe the frequency and related factors of late clinical manifestations of CHIKV infection among imported cases living in Aquitaine area, France.Study designAll patients recruited through the travel clinic and tropical medicine unit of the University Hospital Centre of Bordeaux with possible CHIKV infection were prospectively recorded, and confirmed cases of CHIKV infection were interviewed 2 years after infection. Factors associated with the persistence of symptoms were determined by multivariate logistic regression.ResultsAmong the 29 cases followed, 17 still suffered from arthralgia 2 years after infection, and most of them had never recovered from the initial phase of the condition. The risk of persistent arthralgia tended to be higher among subjects with low educational level, subjects infected in the Reunion Island, and when initial phase lasted 30 days or more and was characterised by a severe pain.ConclusionsConsistent with previous studies, our findings showed worsened late manifestations among patients returning from Indian Ocean area. Persistence of symptoms tended to be linked with clinical burden during the acute phase, which can be informative for early recognition and management of patients at risk for developing persistent rheumatic symptoms. Cryoglobulins failed to be identified in seronegative patients with invalidating dengue-like syndrome. |
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