胰腺癌区域灌注化疗的并发症及其防治

目的　评价区域灌注化疗对胰腺癌的效果并探讨相关并发症的防治。方法　对 36例不能切除的胰腺癌行选择性动脉插管 ,并予 5 氟脲嘧啶、阿霉素、顺铂 (5 Fu、ADM、DDP)行区域灌注化疗。结果　 31例患者接受 6 5周期化疗 ,完全缓解 6例 ,部分缓解 15例 ,行胰十二指肠二步切除 1例。平均生存 9.3± 4.2个月 ,发生各类并发症 14例 ,死亡 2例。结论　胰腺癌区域灌注化疗可改善患者生活质量 ,延长患者生存期 ,但也应重视并发症的防治。

MANAGEMENT OF COMPLICATIONS OF REGIONO-PERFUSIONAL CHEMOTHERAPY OF PANCREATIC ADENOCARCINOMA

Objective To evaluate the effect of regiono-perfusional chemotherapy of pancreatic adenocarcinoma, and to seek the management of its complications. Methods Thirty-six patients with unresectable pancreatic adenocarcinoma received selectively intra-arterial catheterization and perfused with 5-Fu, ADM, DDP. Results Six patients had complete response, 15 partial response, and one underwent radical resection subsequently. Cmplications occurred in 14 patients with 2 patients died of complications. Conclusion Regiono-perfusional chemotherapy of pancreatic adenocarcinoma is effective, but the complications can not be neglected.