幼年性息肉和幼年性息肉病回顾性病理分析

目的 了解我国幼年性息肉病（JPS）不典型增生改变的存在，比较单发结、直肠幼年性息肉（JP）和JPS的不同病理特点。方法 32例单发结、直肠JP标本和5例JPS（共35枚息肉）标本经常规切片，HE染色后进行病理检查，观察不典型增生改变情况并进行分级。结果 32枚单发结、直肠JP未见不典型增生改变。5例JPS的35枚息肉中4例24枚息肉（68.6%)局部有不典型增生改变，其中轻度16枚，中工7枚，重度1枚。结论 JPS和单发结、直肠JP病理改变不完全相同。前才由于息肉是多发的，个别息肉局部可出现不典型增生改变，因而多认为是癌前病变，后者多为良性病变。

Pathologic analysis of dysplastic changes in juvenile polyps and juvenile polyposis syndrome

Objective To investigate the dysplastic changes in juvenile polyposis syndrome (JPS)and to compare different morphologic characteristics between solitary colorectal juvenile polyps(JP) and JPS. Methods A total of 32 routine specimens from 32 cases with JP and 35 specimens from 5 cases with JPS were included in this research . Hematoxylin and eosin (HE) stained sections were used to evaluate the presence and grades of dysplasia. Results There was no dysplastic changes shown in 32 cases of solitary colorectal JP , but in 24 out of 35 JPS(68.6%), there were dysplastic changes from 4 out of 5 cases (16 mild grade, 7 moderate grade and 1 severe grade). Conclusions The pathological changes of polyps in JPS were different from those of polyps in JP. In the former the polyps was generally multiple, occasionally with non-typical dysplastic changes , which was considered to be a potentially precancerous condition; while those in the latter were benign lesions.