The influence of isotopic and nonisotopic carriers on the biodistribution and biokinetics of M3+-citrate complexes |
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| Authors: | Klaus Schomäcker Wolf-Gunther Franke Erhard Henke Wolf-Dieter Fromm Gabriele Maka Gerd-Jürgen Beyer |
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| Affiliation: | (1) Central Institute for Nuclear Research, Academy of Science of the GDR, Rossendorf, 8051 Dresden, POB 19, Dresden, German Democratic Republic;(2) Clinic of Nuclear Medicine, Medical Academy !["ldquo"]("/content/pr3hu7r0v660p874/xlarge8220.gif") Carl-Gustav-Carus!["rdquo"]("/content/pr3hu7r0v660p874/xlarge8221.gif") Dresden, Dresden, German Democratic Republic |
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| Abstract: | The influence of carrier amounts of Fe, Ga, and Tm on the biodistribution of 67Ga-, 59Fe-, and 167Tm-citrate in mice was investigated. Our results suggest that 167Tm, unlike 67Ga and 59Fe, is not transported by transferrin in the blood. Of the three radioisotopes tested, 167Tm had the highest tumor/background ratio (10 h after the injection). The application of Fe carrier led to an enhancement of the elimination of 67Ga from the blood and muscles, resulting in a better tumor/background ratio. |
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| Keywords: | Gallium citrate Ga 67 Ferrous citrate Fe 59 Thulium citrate Tm 167 Transferrin Tumor cells Blood clearance Radionuclide kinetics |
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