| 胃癌组织中基质金属蛋白酶-2和组织基质金属蛋白酶抑制剂-2的表达及其与临床病理特征的关系 |
| |
| 引用本文： | 倪元峰,罗天航,聂明明,马立业,毕建威,华积德.胃癌组织中基质金属蛋白酶-2和组织基质金属蛋白酶抑制剂-2的表达及其与临床病理特征的关系[J].上海医学,2009,32(2). |
| |
| 作者姓名： | 倪元峰 罗天航 聂明明 马立业 毕建威 华积德 |
| |
| 作者单位： | 第二军医大学附属长海医院普外科,上海,200433 |
| |
| 摘 要： | 目的 探讨基质金属蛋白酶-2(MMP-2)和组织基质金属蛋白酶抑制剂-2(TIMP-2)在人胃癌组织中的表达,及其与胃癌临床病理特征的关系.方法 选取100个胃癌手术切除标本中胃癌组织、癌旁组织及正常胃组织,采用免疫组织化学法检测MMP-2和TIMP-2蛋白的表达,并分析两者的表达及其与胃癌临床病理特征之间的相关性.结果 胃癌组织中的MMP-2蛋白阳性率为77.0%,显著高于癌旁组织的33.0%和正常胃组织的8.0%(P值均＜0.01),癌旁组织又显著高于正常胃组织(P＜0.01).胃癌组织中的TIMP-2蛋白阳性率为29.0%,显著低于癌旁组织的62.0%和正常胃组织的76.0%(P值均＜0.01),癌旁组织又显著低于正常胃组织(P＜0.01).随着肿瘤浸润深度的增加(Tis～T4)、周围淋巴结转移的增多(N0～N3)、临床分期的进展(0～Ⅳ期),MMP-2蛋白阳性率逐渐升高,TIMP-2蛋白阳性率逐渐降低,且差异有统计学意义(P值均＜0.01).结论 MMP-2和TIMP-2的表达可能与胃癌的发生、侵袭和转移有关,检测MMP-2和TIMP-2的表达有助于预测胃癌转移.
|
| 关 键 词： | 基质金属蛋白酶-2 组织基质金属蛋白酶抑制剂-2 胃癌 临床病理特征 |
Relationship of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression with clinicopathological properties of human gastric cancer |
| |
| NI Yuanfeng,LUO Tianhang,NIE Mingming,MA Liye,BI dianwei,HUA Jide.Relationship of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression with clinicopathological properties of human gastric cancer[J].Shanghai Medical Journal,2009,32(2). |
| |
| Authors: | NI Yuanfeng LUO Tianhang NIE Mingming MA Liye BI dianwei HUA Jide |
| |
| Institution: | NI Yuanfeng,LUO Tianhang,NIE Mingming,MA Liye,BI Jianwei,HUA Jide. Department of General Surgery,Changhai Hospital,Second Military Medical University,Shanghai 200433,China |
| |
| Abstract: | Objective To investigate the expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in human gastric cancer and its relationship with the clinicopathological properties of human gastric cancer. Methods A total of 100 surgical specimens were investigated by S-P immunohistochemical staining using an anti-MMP-2 monoclonal antibody and an anti-TIMP-2 polyclonal antibody. The expression of MMP-2 and TIMP-2 in various regions of the gastric cancer tissues,paracancero... |
| |
| Keywords: | Matrix metalloproteinase-2 Tissue inhibitor of metalloproteinase-2 Gastric cancer Clinicopathologic feature |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
