肺癌患者与发病前心理社会因素关系的病例对照研究

本文病例组为原发性肺癌３０９例,人群对照组１２３１例,在ＳＡＩＮＯ－ＭＯＮＩＣＡ（ＷＨＯ）项目的监测人群中进行病例对照研究,试图探索肺癌患者与发病前６项心理社会因素的关系。结果有３项与肺癌呈阳性关联;即情绪不能自我调节,人际关系包括同事关系差,上下级关系差和精神长期受夺抑,如将精神长期受凶作为危险因素,按其人群暴露率８．８％计算,其人群归因危险度百分数为２１．６％。

Study on the Relationship between Lung Cancer at Preclinic Stage and Psycho-social Factor-A Case-Control Study

A case-control study of primary lung cancer patients including 309 case (male 193, female 116) and 1231 controls (male 768, female 463) was carried out in the monitored population for SINO-MONICA Project (WHO) during 1990-1993. This was a population based case-control study involved 0.75 million population in order to detect the relationship between lung cancer at preclinic stage and 6 psychosocial factors. There were 3 factors positively associated with lung cancer. They were 1) burst of "emotion and could not be controlled" (OR 1.82 P<0.01), 2) "poor working circumstances" including poor relationship with colleagues (OR 1.37 P<0.05) and superiors (OR 1.55 P<0.01) and the"depressive feeling for a long time" (OR 4.14 P<0.01). when we considered "long standing depressive feeling" as a risk factor for lung cancer and calculated by an exposure rate of 8.8%, the population attributable risk percent (PAR%) would be 21.6% (male 18.7%, female 26.4%). Our findings suggested that the relationship between lung cancer at preclinic stage and psycho-social factor did exist.