Mitochondrial-targeted nanoparticles: Delivery and therapeutic agents in cancer期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Mitochondrial-targeted nanoparticles: Delivery and therapeutic agents in cancer

Institution:	1. Department of Hematology and Oncology, School of Medicine, University of Alabama, Birmingham, AL 35201, USA;2. Department of Oncology, Albert Einstein College of Medicine, Bronx, NY 10461, USA

Abstract:	Antitumor agents are delivered via nanoparticles (NPs) to the mitochondria. The drugs attack the mitochondria resulting in mitochondrial damage and the release of cytochrome C (Cyto-C). Cyto-C binds with Apaf1 and Caspase-9 to form an apoptosome. The apoptosome activates Caspase 3, which ultimately results in the death of cancer cells. Download : Download high-res image (143KB) Download : Download full-size image

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