Characterization of plasma daptomycin in patients with serum highly glycated albumin and obesity |
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| Affiliation: | 1. Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan;2. Department of Pharmacy, Shinshu University Hospital, Matsumoto, Nagano, Japan;1. Service de Microbiologie, Hôpital Européen Georges Pompidou, APHP-Centre, Université Paris Cité, Paris, France;2. Centre National de Référence des Rickettsia, Coxiella et Bartonella, IHU Mediterranée-Infection, Marseille, France;1. Division of Laboratory Medicine, Sapporo Medical University Hospital, Japan;2. Department of Infection Control and Laboratory Medicine, Sapporo Medical University School of Medicine, Japan;3. Division of Infection Control, Sapporo Medical University Hospital, Japan;4. Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan;1. Department of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan;2. Department of Dermatology, Toranomon Hospital, 2-2-2 toranomon, minato-ku, Tokyo, 105-8470, Japan;3. Department of Infectious Diseases, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo, 193-0944, Japan;1. Department of Microbiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan;2. Department of Clinical Infectious Diseases, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan;3. Clinical and Research Center for Infectious Diseases, Toyama University Hospital, Toyama, Japan;1. Faculty of Foreign Studies, Department of Spanish & Latin American Studies, Nanzan University, Aichi, Japan;2. Division of Infection Control Sciences, Department of Clinical Pharmacy, School of Pharmacy, Showa University, Tokyo, Japan;3. School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan;4. Sección Política, Embajada del Japón en Bolivia, La Paz, Bolivia;5. Servicio de Endoscopia Digestiva H.A.I.G. Obrero No.1, C.N.S, La Paz, Bolivia;6. Department of Neurology, Hokuto Hospital, Hokkaido, Japan;7. Dirección General de Epidemiología, Ministerio de Salud y Deportes, La Paz, Bolivia;8. Dirección General de Planificación, Ministerio de Salud y Deportes, La Paz, Bolivia;9. Sección Salud, Embajada del Japón en Bolivia, La Paz, Bolivia;1. Department of Surgery, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima City, Hiroshima Prefecture, 734-8551, Japan;2. Department of Infectious Diseases, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima City, Hiroshima Prefecture, 734-8551, Japan;3. Department of Clinical Pharmacotherapy, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima City, Hiroshima Prefecture, 734-8551, Japan |
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| Abstract: | PurposePlasma daptomycin has not been fully characterized in diabetic and obese patients. This study aimed to evaluate the associations of plasma daptomycin with glycation of serum albumin and obesity.MethodsInfectious patients (n = 70) receiving intravenous daptomycin were enrolled. The plasma concentration of total and free daptomycin were determined using liquid chromatograph-tandem mass spectrometer. The associations of the plasma concentrations of daptomycin with clinical factors including serum albumin fractionations and physical status (obese including overweight, body mass index ≥ 25.0) were investigated. Daptomycin doses were adjusted using total body-weight.ResultsThe serum albumin level was positively and negatively correlated with the plasma concentration of total daptomycin and its free fraction proportion, respectively. The serum non-glycated albumin was negatively correlated with the free fraction proportion. The dose-normalized plasma concentration of total daptomycin was higher in the obese patients than in non-obese patients when the body-weight was corrected with total and adjusted values. For the dose adjustment with lean body-weight, no difference was observed in the dose-normalized plasma concentration of total daptomycin between the physical statuses. For each body-weight correction method, physical status did not affect the dose-normalized plasma concentration of free daptomycin.ConclusionThe glycation of serum albumin and obesity did not associate with dose-normalized plasma free daptomycin. In obese patients, daptomycin dosage adjustment with total body-weight and adjusted body-weight may lead to an apparent excessive exposure resulting in overdosage compared to lean body-weight. |
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| Keywords: | Daptomycin Pharmacokinetics Diabetes Obesity Body-weight correction DAP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" daptomycin MRSA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" methicillin-resistant " },{" #name" :" italic" ," _" :" Staphylococcus aureus tDAP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" total daptomycin fu" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" unbound fraction proportion fDAP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" free daptomycin CK" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" creatine phosphokinase FBS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" fasting blood glucose TBW" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" total body-weight ABW" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" adjusted body-weight LBW" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" lean body-weight eGFR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" estimated glomerular filtration rate IQR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" interquartile range BMI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" body mass index WHO" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" World Health Organization IBW" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," _" :" ideal body weight |
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