| 4-碘苯甲氧基乙酸二甲氨基乙酯的抗心律失常作用 |
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| 引用本文： | 宋哲洙,李明洙,张红英,朴世浩,崔顺玉,李柱天,朱春琴,全城实. 4-碘苯甲氧基乙酸二甲氨基乙酯的抗心律失常作用[J]. 延边医学院学报, 1991, 0(1) |
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| 作者姓名： | 宋哲洙 李明洙 张红英 朴世浩 崔顺玉 李柱天 朱春琴 全城实 |
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| 作者单位： | 延边医学院药理学教研室，延边医学院药学系，延边医学院药理学教研室，延边医学院药理学教研室，延边医学院药理学教研室，延边医学院药理学教研室，延边医学院药理学教研室，白求恩医科大学神经生长研究室 |
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| 摘 要： | 一次iv4-碘苯甲基乙酸二甲氮基乙酯30,60mg/kg,均能明显提高乌头碱所致大鼠室早、室颤和致死的阈剂量,也能提高哇巴因致豚鼠室早、室颤和致死的阀剂量,能显著减少CaCl_2引起的大鼠室颤发生率和死亡率。对BaCl_2所致心律失常及心博停止的阀剂量也有一定的提高作用。小白鼠尾静脉注射的LD_(50)为122.12mg/kg。
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| 关 键 词： | 抗心律失常药 氧化钙类 心室纤颤 哇巴因 |
Anti-arrhythmic effects of dimetylaminoethyl (4-iodophenylmethyloxy) acetate |
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| Song Zhezhu,Li Mingzhu,Zhang Hongying,Pao Shihao,Cui Shunyu,LiZhutian,Zhu Chunchin,Quan Chengshi. Anti-arrhythmic effects of dimetylaminoethyl (4-iodophenylmethyloxy) acetate[J]. Journal of Medical Science Yanbian University, 1991, 0(1) |
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| Authors: | Song Zhezhu Li Mingzhu Zhang Hongying Pao Shihao Cui Shunyu LiZhutian Zhu Chunchin Quan Chengshi |
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| Abstract: | The effect of dimethyl aminoethyl (4-iodophenyl methyloxy) acetate on arrhythmias induced by aconitine, ouabain, barium chloride and calcium chloride was studied. DMEIPA 30 mg/kg or 60 mg/kg iv elevated the threshold doses of aconitine or BaCl_2-induced arrhythmias in rats, also has protective effects of ouabain necessary to induce ventricular premature beats in guinea pigs. Pretreatment of rats with DMEIPA30 or 60mg/kg iv significantly reduced the incidence of ventricular fibrillation induced by CaCl_2 130 mg/kg and reduced the mortality as well. LD_(50) of DMEIPA iv in mice is 522.12 mg per kg. |
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| Keywords: | anti-arrhythmia agent ouabain ventricular fibrillation calcium chloride |
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