早发冠心病并发高血压病患者血浆结合珠蛋白水平与冠状动脉病变程度的相关性

目的:分析早发冠心病并发高血压病患者血浆结合珠蛋白（haptoglobin,Hp）水平的变化及其与冠状动脉病变严重程度的相关性。方法: 经冠脉造影确诊的早发冠心病患者90例，非冠心病的健康体检者90例作为对照组，据血压水平分类将90例早发冠心病患者分为3个亚组:正常血压及正常高值亚组（亚组1）、Ⅰ级和Ⅱ级高血压亚组（亚组2）、Ⅲ级高血压亚组（亚组3）。检测血浆Hp浓度，比较冠心病组与对照组血浆Hp浓度的差异；分析早发冠心病不同临床亚组间血浆Hp浓度、Gensini积分的差异及分析二者的相关性。结果: 早发冠心病组的血浆Hp浓度明显高于对照组，比较有统计学差异（P<001）。早发冠心病组3个亚组的Hp血浆浓度分别为（16±05） μg/L、（17±04） μg/L和（20±06） μg/L，3组之间差异有统计学意义（P<005）。两两比较，亚组3的Hp血浆浓度高于亚组1和亚组2，差别有统计学意义（均P<005）。3个亚组Gensini积分分别为（32±19）、（33±18）和（48±28），3亚组之间差异有统计学意义（P<005）。两两比较，亚组3的Gensini积分高于亚组1和亚组2，差别有统计学意义（均P<005），而亚组1与亚组2的Hp浓度和Gensini积分均无显著差异。结论: Hp水平的升高与早发冠心病的发生及冠脉狭窄的严重程度有关。

Clinical significance of plasma haptoglobin levels in patients with premature coronary heart disease with essential hypertension

AIM:To investigate the clinical significance of the variations of blood plasma haptoglobin (Hp) in premature coronary heart disease (PCAD) patients with essential hypertension and to study the clinical correlations between the level of plasma Hp and PACD essential hypertension. METHODS: Ninety patients with PACD confirmed by coronary angiography were enrolled in this study and 90 healthy subjects were selected as control. According to the levels of blood pressure (Bp), the patients were divided into three groups: normal Bp group, Grade 1 Bp and Grade 2 group, and Grade 3 Bp group. Plasma levels of Hp were detected, plasma Hp levels between PACD groups and control group were compared and plasma Hp levels and Gensini scores and their correlation were analyzed in the three groups. RESULTS: Plasma levels of Hp in patients with PACD were significantly higher than the levels in control subjects (P<005). Plasma levels of Hp in the three PACD groups were (16±05) ng/ml, (17±04) ng/ml and (20±06) ng/ml, respectively, with significant differences among the three groups (P<005). Gensini scores in the three PACD groups were 32±19, 33±18 and 48±28, respectively, with significant difference among the three groups (P<005). The plasma level of Hp and Gensini score in Grade 3 group was higher than the level in the other two groups (P<005). CONCLUSION: Plasma Hp level has some clinical significance for diagnosis of PACD and assessment of degree of coronary stenosis along with its correlation with the development and advancement of PACD and with the degree of coronary stenosis.