血清中白介素-17和白介素-10水平与心房颤动的相关性

目的:探讨左心房和右心房的白介素-17(IL-17)和白介素-10(IL-10)的水平与心房颤动(房颤)发生的关系。方法:选择42例房颤患者,其中阵发性房颤24例,持续性房颤18;选择阵发性室上速或预激综合征患者17例为对照组。通过ELISA方法检测左心房和右心房IL-10和IL-17水平,并使用心脏超声心动图测量左心房长径。分析血清中IL-10和IL-17细胞因子的水平与房颤左房结构重构程度的关系。结果:房颤组左心房和右心房IL-17明显高于对照组(均P<0.01);房颤组IL-10显著高于对照组(左心房:P<0.01,右心房:P<0.05)。结论:IL-17、IL-10与房颤相关。IL-17升高水平与左心房内径成正比。

Levels of interleukin 17 and interleukin 10 in serum of patients with atrial fibrillation

AIM: To study the levels of IL-17 and IL-10 in left and right atrium serum of patients with atrial fibrillation(AF) and to investigate their relation with the progression of atrial fibrillation.METHODS: Forty-two patients with AF,including 24 paroxysmal atrial fibrillation patients and 18 persistent atrial fibrillation patients and a control group of 17 selective paroxysmal supraventricular tachycardia or pre-excitation syndrome patients were included in the study.The levels of IL-17 and IL-10 in serum from left and right atrium evaluated by ELISA and the left atrial long diameters measured by cardiac ultrasound heartbeat graph were used to study the association between IL-17 and IL-10 in serum and AF left atrial structural remodeling.RESULTS: Levels of IL-17 and IL-10 in left and right atrium serum from patients with AF were both higher than those of controls(P<0.01,P<0.01,P<0.01,P<0.05,respectively).CONCLUSION: IL-17 and IL-10 in serum are significantly related to development of AF and may play an important role in the progression of AF.