浙江省绍兴地区宫颈人乳头瘤病毒感染流行病学调查

目的 了解浙江省绍兴地区女性宫颈人乳头瘤病毒(human papilloma virus, HPV)感染及亚型分布状况,为针对我国女性生殖器疣、宫颈癌防治,HPV疫苗的研制与推广提供参考。 方法 采用回顾性观察分析法,收集2008年1月至2012年10月在绍兴市妇幼保健院对健康体检女性进行宫颈HPV感染筛检者,统计分析其HPV感染及亚型分布情况。 结果 5521名健康体检女性,HPV总感染754例,总感染率为13.7%(754/5521)。其中高危型感染占83.7%(631/754),低危型感染占14.3%(108/754);单一感染占85.1%(642/754),多重感染占14.9%(112/754);21个亚型中HPV-16感染位居首位,占22.5%(170/754),其次依次为HPV-52,HPV-58, HPV-cp8304和HPV-33;各年龄段总HPV感染率差异无统计学意义(P结论 绍兴地区普通女性HPV总感染率为13.7%,以高危型、单一感染为主,排名前10位亚型依次为16、52、58、cp8304、33、11、18、53、6、68。HPV亚型分布存在地区差异。

Epidemiological survey of cervical infection of human papilloma virus among women in Shaoxing,Zhejiang

Objective To understand the cervical infection status of human papilloma virus (HPV) among women and the prevalent HPV genotype distribution in Shaoxing, Zhejiang province, and provide evidence for female genital warts and cervical cancer prevention and treatment as well as the development and wide use of HPV vaccine. Methods Retrospective analysis was conducted on the HPV detection data of women receiving health examination in our center from January 2008 to October 2012. Results Among 5521 women receiving health examination, 754 were infected with HPV (13.7%).The high risk infection accounted for 83.7% (631/754) and the low risk infection accounted for 14.3% (108/754). Simple infection accounted for 85.1% (642/754), mixed infection accounted for 14.9% (112/754). HPV-16 ranked first among 21 HPV genotypes, accounting for 22.5% (170/754), followed by HPV-52, 58, cp8304 and 33. There was no statistical difference in age specific HPV infection rate (PConclusion The overall HPV infection rate was 13.7% among the women in Shaoxing. High risk simple infection was prevalent. The first 10 HPV genotypes detected were 16, 52, 58, cp8304, 33, 11, 18, 53, 6 and 68. The distribution of HPV genotype varied with areas.