5-氟脲嘧啶对胰腺外分泌的影响

目的 探讨5-氟脲嘧啶(5-FU)对人胰腺外分泌功能的影响。方法 通过8例胰十二肠切除术后患者胰管内置管获得的纯胰液观察5-FU对人胰腺外分泌功能的作用。术后第10天开始，静脉缓慢滴注5-FU500mg／d，连续3天。检测5-FU使用前和使用后1d、2d及3d胰液中淀粉酶、pH、HCO3^-、Na^ 、K^ 、Cl^-、Ca^2 及Mg^2 水平，并记录胰液量变化。结果使用5-FU前、后胰液量及胰液中淀粉酶、pH、HCO3^-、Na^ 、K^ 、Cl^—、Ca^2 及Mg^2 水平均无显著变化。结论 短期内使用5—FU对胰腺外分泌功能未见明显影响，5-FU是否通过抑制胰酶的合成治疗急性胰腺炎有待进一步探讨。

Effect of 5-Fluorouracil on the Exocrine Pancreas

Objective To observe the effect of 5 Fluorouracil(5 FU) on the exocrine pancreas. Methods The effects of 5 FU were investigated in 8 patients who had undergone pancreatoduodenectomy. The pancreatic juice was temporarily diverted to the exterior via a pancreatic duct catheter.Ten days after operation,the patients were injected intravenously with 5 FU 500 mg/d for three days. The samples of pancreatic juice were taken for measurement of amylase,pH, HCO 3 -, Na +, K +, Cl -, Ca 2+ and Mg 2+ .Results The amylase, pH, HCO 3 -, Na +, K +, Cl -, Ca 2+ and Mg 2+ did not alteredsignificantly before and after 5 FU injection.Conclusion 5 FU has no short term effect on exocrine pancreas. Therefore, improvement of acute pancreatitis cannot be achieved through inhibiting pancreatic enzymes synthesis.