血清铁蛋白、β_2－微球蛋白和癌胚抗原放免测定对诊断卵巢恶性肿瘤的初步评价

目的探讨血清铁蛋白（ＳＦ）、β２－微球蛋白（β２－ＭＧ）和癌胚抗原（ＣＥＡ）在诊断卵巢恶性肿瘤中的价值。方法用放射免疫法测定卵巢肿瘤６１例和健康女性３５例的ＳＦ、β２－ＭＧｆｏＣＥＡ水平。结果卵巢恶性肿瘤患者的ＳＦ、β２－ＭＧ和ＣＥＡ均高于良性肿瘤组和正常对照组；Ⅲ～Ⅳ期者ＳＦ高于Ⅰ～Ⅱ期者；ＳＦ和β２－ＭＧ联合检测优于单项检测，Ⅰ～Ⅱ期患者的诊断敏感性达６３．６４％。结论ＳＦ和β２－ＭＧ测定简单易行，是卵巢恶性肿瘤的良好诊断指标。

Radioimmunoassay of ferritin.β_2-MG .and CEA in serum for diagnosis of malignant ovarian neoplasm

To study the value of ferritin (SF) , Beta2-microglobulin (β2-MG ) and carcinoembryonic antigen (CEA) for the diagnosis of malignant ovarian neoplasm.Methods Sixty-one patients of ovarian neoplasm and 35 healthy subjects were as sayed for SF,β2-MG and CEA with radioimmunoassay.Results The average content of tumor markers in ovarian cancer was higher than that in the benign and healthy subjects. The level of SF was higher in stage Ⅲ and Ⅵ patients of ovarian cancer than that in stage Ⅰand Ⅱ. Combined SF and β2-MG were superior to using one marker for the diagnosis of ovarian cancer. The diagnostic sensitivity was 63. 64% in stage Ⅰ andⅡ patients of ovarian64. cancer.Conclusions The method of detecting SF and β2-MG was simple and easy. SF and β2-MG may be good tumor markers for malignant ovarian neoplasm.