Post-learning REM sleep deprivation impairs long-term memory: Reversal by acute nicotine treatment |
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Authors: | AM Aleisa KH Alzoubi KA Alkadhi |
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Institution: | 1. Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;2. Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan;3. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204-5037, United States |
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Abstract: | Rapid eye movement sleep deprivation (REM-SD) is associated with spatial learning and memory impairment. During REM-SD, an increase in nicotine consumption among habitual smokers and initiation of tobacco use by non-smokers have been reported. We have shown recently that nicotine treatment prevented learning and memory impairments associated with REM-SD. We now report the interactive effects of post-learning REM-SD and/or nicotine. The animals were first trained on the radial arm water maze (RAWM) task, then they were REM-sleep deprived using the modified multiple platform paradigm for 24 h. During REM-SD period, the rats were injected with saline or nicotine (1 mg/kg s.c. every 12 h: a total of 3 injections). The animals were tested for long-term memory in the RAWM at the end of the REM-SD period. The 24 h post-learning REM-SD significantly impaired long-term memory. However, nicotine treatment reversed the post-learning REM-SD-induced impairment of long-term memory. On the other hand, post-learning treatment of normal rats with nicotine for 24 h enhanced long-term memory. These results indicate that post-learning acute nicotine treatment prevented the deleterious effect of REM-SD on cognitive abilities. |
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Keywords: | Nicotine Sleep deprivation Post-learning Memory Hippocampus Maze |
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