Mice lacking rhes show altered morphine analgesia,tolerance, and dependence |
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Authors: | Franklin A Lee Brandon A Baiamonte Daniela Spano Gerald J LaHoste R Denis Soignier Laura M Harrison |
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Institution: | 1. Department of Psychology, University of New Orleans, New Orleans, LA 70148 United States;2. Dipartimento di Biochimica e Biotecnologie Mediche, Universita di Napoli, Naples, Italy;3. Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, United States |
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Abstract: | Rhes, the Ras Homolog Enriched in Striatum, is an intermediate-size GTP binding protein. Although its full functions are not yet known, it has been shown to affect signaling and behaviors mediated by G protein-coupled receptors. Here we have tested whether Rhes affects behaviors mediated by opioid receptors. Wild type and rhes-deficient mice were administered morphine and tested for analgesia in formalin and tail flick tests. Rhes−/− mice showed significantly enhanced analgesia in both tests relative to rhes+/+ mice. Furthermore, rhes−/− mice did not display tolerance to repeated morphine administration and displayed significantly less withdrawal than rhes+/+ mice. These findings indicate that Rhes is involved in behaviors mediated by mu opioid receptors and in the adaptive response to repeated morphine administration. |
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Keywords: | RASD2 Opioid Tolerance Analgesia Dependence GTP-binding protein |
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