Endocrine immune interactions in human parturition |
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Authors: | E Golightly HN Jabbour JE Norman |
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Institution: | 1. University of Edinburgh, Division of Reproductive and Developmental Sciences, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom;2. The Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen''s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom |
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Abstract: | Human parturition is an inflammatory event, modulated and influenced by a host of other environmental and physiological processes, including the endocrine hormones. Complex bidirectional communication occurs between the two systems to bring about some of the changes that are seen in labour, an event that is not yet fully understood. Preterm birth is a major problem in obstetrics and neonatology, with dysfunctional labour or prolonged pregnancy also making increasingly significant contributions to maternal morbidity. With better understanding of normal and abnormal parturition we may be able to develop novel ways of treating these complications of pregnancy and reduce maternal and neonatal morbidity and mortality. This review discusses the crucial role that endocrine–immune interaction plays in the process of labour and in the processes of abnormal and preterm labour. We propose that amongst these complex interactions it is the immune system that is the driving force behind human parturition. |
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Keywords: | Parturition Endocrine Inflammation Immune |
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