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Effect of COMT genotype on aggressive behaviour in a community cohort of schizophrenic patients |
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| Authors: | Sarah Tosato Chiara Bonetto Marta Di Forti David Collier Doriana Cristofalo Mariaelena Bertani Martina Zanoni Giovanna Marrella Lorenza Lazzarotto Antonio Lasalvia Marzia De Gironcoli Michele Tansella Paola Dazzan Robin Murray Mirella Ruggeri |
| Institution: | 1. Section of Psychiatry and Clinical Psychology, University of Verona, Italy;2. Blood Transfusion Service, Azienda Ospedaliera Universitaria Integrata di Verona, Italy;3. Institute of Psychiatry, King''s College London, UK;4. SGDP Centre, Institute of Psychiatry, King''s College London, UK |
| Abstract: | Although the etiology of aggression is multifactorial, many studies have associated the Val158Met polymorphism of the COMT with aggression in schizophrenia. This study tests the hypothesis that Met/Met patients display more episodes of aggression and violent behaviour than Val/Val patients in a 6 year follow-up cohort of subjects with schizophrenia in contact with the South-Verona Community-based Mental Health Service. Out of the 141 subjects with an ICD-10 SCAN-confirmed diagnosis of schizophrenia, 115 completed both baseline and follow-up assessments (81.6% of the baseline cohort). Of these, 80 subjects (70%) were genotyped and rated for aggression using the Overt Aggression Scale. |
| Keywords: | Aggression COMT Schizophrenia Outcome |
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