Autoimmune phenomena of the external eye. |
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| Authors: | B J Mondino S I Brown B S Rabin |
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| Institution: | 1. From the Department of Ophthalmology, University of Pittsburgh School of Medicine and Eye and Ear Hospital;2. Division of Clinical Immunopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh |
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| Abstract: | The immunologic status of patients with ocular pemphigoid, Mooren's ulcer, chronic herpetic keratitis, and staphylococcal peripheral corneal ulcers was studied. Although tissue-fixed and circulating antibodies to the conjunctival epithelium were found in all groups, patients with Mooren's ulcer demonstrated these findings most consistently. Immunoglobulins bound to the conjunctival basement membrane were found not only in ocular pemphigoid but also in patients with Mooren's and staphylococcal ulcers. Approximately one half of the patients with ocular pemphigoid and Mooren's ulcer demonstrated elevations in serum IgA levels. An increased prevalence of HLA-B12 was found in ocular pemphigoid. |
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| Keywords: | Autoimmune antibodies corneal ulcer Mooren's ulcer ocular cicatricial pemphigoid staphylococcal peripheral corneal ulcerations chronic herpetic keratitis |
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