泰泽病原体研究现状

泰泽病原体(Tyzzer’s organism或Bacillus piliformis或Clostridium piliformis)是一种带鞭毛、菌毛、芽胞，专营细胞内寄生的革兰阴性杆菌。该菌广泛存在于实验动物、家禽、家畜、宠物及非人灵长类，引起动物的出血坏死性肠炎和粟粒状肝坏死。对人的潜在威胁已经引起了人们的关注。由于不能在无活细胞的人工培养基上生长、繁殖和自溶性，导致目前对该菌的生物学特性、致病机理、遗传学、诊断和检测方法以及泰泽病的预防始终没有突破性进展。本文就泰泽病原体的生物学特性、感染和传播、致病机理和病理变化等方面作一个简要的综述。

Study on Tyzzer''s Organism

Tyzzer's organism is a flagellar, pilial, rod-shaped, gram-negative, sporeforming, obligate intracellular Clostridium. It abroad indwells laboratory animals, fowls, domestic animals, pets, and inhuman primates. Tyzzer's organism mostly causes diseases with hemorrhage, necrotic enteritis and little granule necrosized hepatitis in laboratory animals. Latent threatening has raised attention to human. Tyzzer's organism can autolyze and not be grown on conventional media with alive cells. These result in no broken improvement in biological characteristics, disease|causing mechanism, genetics, diagnose and detecting methods of Tyzzer's organism, prevention and cure of Tyzzer's disease. This text makes a brief summary in biological characteristics, infection and spread, disease|causing mechanism and pathology of Tyzzer's organism.