| 再生障碍性贫血患者T细胞亚群与抑制细胞的活性 |
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| 引用本文： | 谭路坚,洪文德,谭恩勋,张国材,吴陈利,赵波,李树浓. 再生障碍性贫血患者T细胞亚群与抑制细胞的活性[J]. 中山大学学报(医学科学版), 1990, 0(3) |
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| 作者姓名： | 谭路坚 洪文德 谭恩勋 张国材 吴陈利 赵波 李树浓 |
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| 作者单位： | 中山医科大学附属第一医院血液病研究室(谭路坚，洪文德，谭恩勋，张国材，吴陈利)，中山医科大学病理生理学教研室(赵波)，中山医科大学病理生理学教研室(李树浓) |
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| 摘 要： | 以抗生物素蛋白-生物素-过氧化酶复合物检测18例再生障碍性贫血(再障)患者外周血T细胞亚群,其中10例同时检测抑制细胞活性。结果表明:再障患者CD_4~+细胞百分率降低,CD_8~+细胞百分率明显增高,CD_4~+/CD_8~+比值明显下降。7/10例STs,显示抑制率低于正常范围,CD_8~+细胞增高,STs示功能下降,两者呈直线负相关系。提示再障的发病机制可能与细胞毒性T细胞作用有关。
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| 关 键 词： | 再生障碍性贫血 T细胞亚群 抑制细胞活性 |
RESEARCH FOR T-LYMPHOCYTE SUBSETS AND SUPPRESSOR CELL ACTIVITY OF APLASTIC ANEMIA |
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| Tan Lujan Hong Wende Tan Enxun Zhang Guocai Wu Chenli Supervisor: Pang Guoyuan. RESEARCH FOR T-LYMPHOCYTE SUBSETS AND SUPPRESSOR CELL ACTIVITY OF APLASTIC ANEMIA[J]. Journal of Sun Yatsen University(Medical Sciences), 1990, 0(3) |
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| Authors: | Tan Lujan Hong Wende Tan Enxun Zhang Guocai Wu Chenli Supervisor: Pang Guoyuan |
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| Affiliation: | Tan Lujan Hong Wende Tan Enxun Zhang Guocai Wu Chenli Supervisor: Pang Guoyuan (Institute of Hematology of First Affiliated Hospital) Zhao Bo Li Shunong(Department of Pathophysiology) |
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| Abstract: | T-lymphocyte subsets were detected with avidin biotin complex (ABC) method in is cases of aplastic anemia and suppressor cell activity was detected in 10 patients at the same time. The results indicated that the CD/ T cell subsets was decreased, the CD8+ T cell subsets was increased, the CD4+/CD8+ ratio was markedly decreased. In 7/10 cases, the suppressor cell activity was lower than normal controls. It suggests that the etiopathology of aplastic anemia may have a relationship with immunodysfunction of T lymphocyte subsets. |
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| Keywords: | Aplastic anemia T-cell subsets Suppressor cell activity |
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