可乐定对梭曼中毒的预防作用(英文)

研究了可乐定对梭曼中毒的预防作用 .结果显示试管内可乐定仅在高浓度 ( 1 - 1 0 mmol· L-1)时对 Ch E产生抑制 ,在小鼠体内 1 mg·kg-1,ip时对脑 Ch E也只产生轻微的抑制 .给小鼠先 ip可乐定对梭曼中毒小鼠脑和全血 Ch E活性无明显影响 ,却使中毒小鼠惊厥发生率及死亡率显著下降 .育亨宾可以明显对抗可乐定对梭曼中毒的预防作用 .说明 α2 肾上腺素受体可能介导了可乐定对梭曼中毒的预防作用 .

Protective effect of clonidine against soman intoxication

Clonidine prophylactic action against soman intoxication was investigated. The results showed that clonidine itself inhibited the brain cholinesterase(ChE) activity only at high concentrations(1-10 mmol·L^-1) in vitro, and didn′t inhibited the brain and blood ChE obviously at 1 mg·kg^-1 ip in mice. The pretreatment of clonidine could not affect the brain and blood ChE activity of soman-intoxicated mice significantly, but it could significantly suppressed the incidence of soman-induced seizure and death. Yohimbine expressed obviously antagonistic action against the protective effect of clonidine in soman intoxication. It suggests that the α₂-adrenergic receptor activation mediate the protective action of clonidine against soman intoxication.