模糊物元模型评价几种促透剂的促透效果

目的：探讨模糊物元模型在促透剂促透效果综合评价中的运用。方法：研究氮酮、薄荷醇、樟脑、油酸、丁香油、荆芥油、藿香油促透剂对模型药物扑热息痛在离体兔背部皮肤上的透皮行为，计算渗透系数、稳态流量、滞后时间、增渗倍数，运用基于变异系数权重的模糊物元模型对促透效果进行综合评价。结果：2%丁香和2%樟脑对扑热息痛的促透效果最好，1%氮酮、2%荆芥、2%薄荷醇、2%油酸次之，2%广藿香最差。结论：基于变异系数权重的模糊物元模型可客观地、公正地评价促透剂的促透效果。

Evaluation of promoting effect of several transdermal enhancers with fuzzy matter-element model

Objective: To discover the utilization of fuzzy matter-element model in evaluating the promoting effect of transdermal enhancers. Method: Paracetamol was used as drug model. Azone, menthol, camphor, oleic acid, clove oil, Schizonepeta tenuifolia oil and patchouli were used as transdermal enhancers. Detecting transdermal absorption experimentation of paracetamol on the device of penetrating skins of rabbit in vitro and calculating penetrating rates, steady fluxs, lag time and enhancement ratio to evaluate promoting effect of transdermal enhancers with fuzzy matter-element model based on variation coefficient weight. Result: As for promoting effect on paracetamol, 2% clove oil and 2% camphor were the best, 1% azone, 2% Schizonepeta tenuifolia oil, 2% menthol and 2% oleic acid ranked behind, 2% patchouli was the worst. Conclusion: The application of fuzzy matter-element model based on variation coefficient weight in synthetical evaluation of promoting effect of transdermal enhancers is objectively and fairly.