五倍子水煎剂对100株溶血葡萄球菌等CNS的体外抗菌活性观察

【目的】采用新的中药抑菌实验方法对五倍子水煎剂进行了100株溶血葡萄球菌等凝固酶阴性葡萄球菌(CNS)体外抗菌活性检测。【方法】将五倍子水煎剂采用醇脂稀释法，用M—H琼脂对五倍子等进行定量抗菌实验。【结果】五倍子水煎剂对溶血葡萄球菌(staphylococcus heamolyticus)等凝固酶阴性葡萄球菌的抗菌活性均较好，其MICl如均为0．051mg／mL(1：10240)，对溶血葡萄球菌和里昂葡萄球菌(S．lugdunensis)的MICm均为0．203mg／mL(1：2560)，对44株人葡萄球菌(S．hominis)等的MIG90为0．203mg／mL(1：2560)。【结论】此项研究为临床治疗由凝固酶阴性葡萄球菌引起的感染，提供了实验依据。

Antibacterial Activity of Galla Chinensis against100Strains of CNS Including Hemolytic Staphylococci in vitro

[Objective] To determine the antibacterial activity of decoction of Galla Chinensis against100strains of coagu-lase-negative Staphylococci(CNS)in vitro by a new method of antibacterial test for traditional Chinese medicine. [Methods] The decoction of Galla Chinensis was diluted with agar and an antibacterial experiment was carried by M-H a-gar. [Result] The antibacterial effect of galla Chinensis against CNS(hemolytic Staphylococci etc)was marked(MIC50:0.051mg/mL,1:10240),and the MIC₉₀against S.heamolyticus and S.lugdunensis was 0.203mg/mL(1:2560).The MIC90 against 44 strains S.hominis etc was0.203mg/mL(1:2560). [Conclusion] The study provided experimental basis for the cure of infection caused by CNS.