葡萄糖6-磷酸异构酶在类风湿关节炎中的诊断意义

目的:探讨葡萄糖6-磷酸异构酶在类风湿关节炎中的诊断意义。方法:应用ELISA方法检测血清中的GPI和抗CCP抗体。结果:①312例RA患者血清GPI平均浓度为(0.86±1.01)μg/ml,333例非RA患者的GPI平均浓度为(0.23±0.54)μg/ml;RA组抗环瓜氨酸(抗CCP)抗体平均浓度是(35.61±45.32)Ru/ml,非RA组抗CCP平均浓度为(2.54±3.85)Ru/ml,均有显著差异;②敏感性:GPI为89.74%,抗CCP为97.56%;特异性:GPI为90.03%,抗CCP为98.71%,均无显著差异;③通过回归分析发现关节肿胀、疼痛与GPI浓度相关。结论:GPI可能成为诊断RA及判断疾病活动性的一个新指标。

Value of glucose-6-phosphate isomerase in patients with rheumatiod arthritis

Objective To investigate the value of glucose-6 -phosphate isomerase(GPI) expression in patients with rheumatiod arthritis (RA).Method ELISA was used to assay the concentration of GPI and anti-CCP antibodies in serum.Results GPI in patients with RA were(0.86±1.01)μg/ml(n =312),and were(0.23±0.54)μg/ml in non-RA patients(P<0.01,n=333).Anti-CCP antibodies were(35.61±45.32) Ru/ml in RA group,were(2.54±3.85) Ru/ml in non - RA group(P<0.01).Sensitivity:GPI were 89.74%, anti-CCP antibodies were 97.56%;Specifity:GPI were 90.03%,anti-CCP antibodies were 98.71%,all had no significant statistical differences;and GPI serum level was positively associated with Swelling and jonit tenderness.Conclusion GPI may be a new marker for diagnosing RA and accessing its activity.