侵袭性血管粘液瘤的临床病理分析

目的 探讨侵袭性血管粘液瘤的临床病理特点及其鉴别诊断。方法 对1例阴道侵袭性血管粘液瘤进行光镜和免疫组化检测观察。结果 镜检:肿瘤细胞梭形或星形,分布于疏松的粘液样背景中,间质血管丰富,血管壁厚薄不均。免疫组化Vimentin、Desmin、ER和PR阳性,SMA、S-100和HMB45阴性。结论 侵袭性血管粘液瘤是一种少见的特征性的间叶性肿瘤,具有鲜明的组织学特点,免疫组化显示肿瘤细胞可能为纤维母细胞/肌纤维母细胞来源。肿瘤呈浸润性生长,容易复发但不转移,须与其他粘液性肿瘤鉴别诊断。

The clinical pathological study of aggressive angiomyxoma

Objective To study the morphologic features and different diagnosis of aggressive angiomyxoma. Methods One case of aggressive angiomyxoma of the viginal was investigated using immunohistochemical method with light microscope. Results Histologically, the stellate and spindled tumor cells scattered in a loosely collagenized matrix with vessels of varied caliber. Immunohistochemically, the tumor cells were positive for vi-mentin,desmin,estrogen receptor and progesterone receptor,but negative for SMA.S-100 and HMB 45. Conclusion Aggressive angiomyxoma is a rare, distinctive mensenchymal neoplasm characterized by infiltration of adjacent structures,absence of distant metastases and a tendency to recur locally. It should be distinguished from malignant myxoid tumors.