| 青藤碱对吗啡依赖大鼠戒断症状及单胺类神经递质的影响 |
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| 引用本文： | 王彩云,莫志贤,朱秋双,文磊.青藤碱对吗啡依赖大鼠戒断症状及单胺类神经递质的影响[J].中药材,2002,25(5):337-339. |
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| 作者姓名： | 王彩云 莫志贤 朱秋双 文磊 |
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| 作者单位： | 第一军医大学中医系,广州,510515 |
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| 摘 要： | 目的：观察中药单体青藤碱对吗啡依赖大鼠的作用。方法：雄性大鼠按剂量递增方法腹腔注射（ip)吗啡形成吗啡依赖模型，经给药治疗后，ip盐酸纳洛酮（1.0mg/kg)观察戒断症状、体重及单胺类神经递质变化。结果：青藤碱能减轻大鼠戒断症状，恢复体重，降低戒断后骤增的单胺类神经递质。结论：青藤碱对吗啡依赖大鼠具有一定治疗作用，其机理可能与调节单胺类神经递质紊乱有关。
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| 关 键 词： | 戒断症状 青藤碱 吗啡依赖 单胺类神经递质 青风藤 |
| 修稿时间： | 2001年11月14 |
Effect of Sinamine on Withdrawal Symptom and Neurotransmitter of Morphine-dependent Rats |
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| Wang Caiyun,Mo Zhixian,Zhu Qiushuang,Wen Lei.Effect of Sinamine on Withdrawal Symptom and Neurotransmitter of Morphine-dependent Rats[J].Jorunal of Chinese Medicinal Materials,2002,25(5):337-339. |
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| Authors: | Wang Caiyun Mo Zhixian Zhu Qiushuang Wen Lei |
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| Institution: | First Military Medical University, Guangzhou 510515. |
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| Abstract: | Objective: To study on the detoxification effect of sinamine in morphine-dependent rats. Methods: Morphine-dependent rats were induced by injecting morphine on dosage increasing by degrees, then treated with medication. The whithdrawal symptoms, body weight and NE, DA, 5-HT in the brain were tested. Results:Sinamine could alleviate whithdrawal symtom, reablement body weight, inhibit neuro-transitter in the brain. Conclusion: Sinamine have effects on morphine-dependent rats which may relate to modulating neurotransitter. |
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| Keywords: | Sinamine Morphine-dependence Withdrawal Neurobansmitter |
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