| 硝苯吡啶前治疗防止体外循环手术中氧自由基释放的临床观察 |
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| 引用本文： | 肖锡俊,田子朴,吴兴健,尹秋熙,黄旭中,袁宏声,石应康. 硝苯吡啶前治疗防止体外循环手术中氧自由基释放的临床观察[J]. 四川大学学报(医学版), 1993, 0(1) |
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| 作者姓名： | 肖锡俊 田子朴 吴兴健 尹秋熙 黄旭中 袁宏声 石应康 |
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| 作者单位： | 华西医科大学心胸外科(肖锡俊，田子朴，黄旭中，袁宏声)，华西医科大学心脏内科(吴兴健，尹秋熙)，华西医科大学心胸外科(石应康) |
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| 摘 要： | 作者用硝苯吡啶前治疗观察其防止体外循环手术中氧自由基释放的作用。选作体外循环手术的20例患者分为对照组和治疗组。治疗组于主动脉阻断前给予硝苯吡啶0.6mg/kg。分别于主动脉阻断前、阻断后15分钟及主动脉开放后30、60、120、180分钟抽血,测定血浆丙二醛(MDA)、黄嘌呤氧化酶(XO)、尿酸(UA)和红细胞超氧化物歧化酶(SOD)。结果表明,硝苯吡啶前治疗能减少体外循环手术中氧自由基释放。
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| 关 键 词： | 硝苯吡啶 体外循环 氧自由基 |
Clinical Observation of the Effect of Pretreatment with Nifedipine in Preventing Oxygen Free Radicals in the Cardiopulmonary Release Bypass Operation |
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| Xiao Xijun,Tian Zipu,Wu Xingjian,Yin Qiuxi,Huang Xuzhong,Yuan Hongsheng,Shi Yingkang. Clinical Observation of the Effect of Pretreatment with Nifedipine in Preventing Oxygen Free Radicals in the Cardiopulmonary Release Bypass Operation[J]. Journal of Sichuan University. Medical science edition, 1993, 0(1) |
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| Authors: | Xiao Xijun Tian Zipu Wu Xingjian Yin Qiuxi Huang Xuzhong Yuan Hongsheng Shi Yingkang |
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| Affiliation: | Xiao Xijun;Tian Zipu;Wu Xingjian;Yin Qiuxi;Huang Xuzhong;Yuan Hongsheng;Shi Yingkang Department of Cardiothoracic Surgery Department of Cardiology |
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| Abstract: | The effect of pretreatmentwith nifedipine in preventing oxygen freeradicals release was observed in thecardiopulmonary bypass (CPB) operation.Twenty cases were divided into twogroups for comparison. Nifedipine(0.6mg/kg)was given to the test group. MDA, XO,UA and SOD were measured. These exa-minations were taken at pre-aortic clamp-ing, 15 min after aortic clamping, and30, 60, 120, 180 min after reperfusion. Theresults indicated that pretreatment withnifedipine reduced oxygen free radicalsrelease in the CPB operation. |
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| Keywords: | Nifedipine Cardiopulmonary bypass Oxygen free radicals |
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