麦角总碱注射液的制备

一、绪言麦角是治疗和预防产后出血不可缺乏的妇科要药。我国对麦角需要量很大,过去完全依赖进口。据近年调查在我国东北、华北地区均产大量野生麦角。对国产麦角的化学分析及药理作用已有研究。近年来在麦角菌的人工接种栽培方面已获得一定的成功。如何利用国产麦角制成制剂以满足临床需用,是迫切需要解决的问题。各国应用的麦角注射制剂有两类:(1)单纯生物碱制剂,如麦角新碱注射液;(2)新

PREPARATION OF ERGOT TOTAL ALKALOIDS FOR INJECTIONS

An injectable aqueous solution of ergot alkaloids was prepared from native ergot by repercolation with 50% alcohol acidified with tartaric acid as menstruum. The alcoholic percolate was extracted with ether and finally with 1% tartaric acid solution. The aqueous solution was assayed colorimetricalty. After its concentration was adjusted to 0.32 mg/ml and filtered, the solution was put into 2 ml ampoules under an atmosphere of carbon dioxide and sterilized at 100°for 30 minutes. Stability studies show that filling the ampoules under CO₂ and adding, 0.1% ascorbic acid and 10 ppm of EDTA markedly improve the stability of the alkaloid.