Is β-APP a marker of axonal damage in short-surviving head injury? |
| |
| Authors: | K J McKenzie D R McLellan S M Gentleman W L Maxwell T A Gennarelli D I Graham |
| |
| Institution: | (1) Department of Neuropathology, University of Glasgow, Glasgow, UK, GB;(2) Department of Anatomy, Charing Cross and Westminster Medical School, London, UK, GB;(3) Laboratory of Human Anatomy, University of Glasgow, Glasgow, UK, GB;(4) Department of Neurosurgery, Medical College of Pennsylvania and Hahnemann University, Philadelphia, Pennsylvania, USA, US;(5) Department of Neuropathology, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital NHS Trust, Glasgow G51 4TF, UK Tel.: 0141-201 2113/2046: Fax: 0141-201 2998, GB |
| |
| Abstract: | β-Amyloid precursor protein (β-APP), a normal constituent of neurons which is conveyed by fast axonal transport, has been
found to be a useful marker for axonal damage in cases of fatal head injury. Immunocytochemistry for β-APP is a more sensitive
technique for identifying axonal injury than conventional silver impregnation. This study was designed to determine how quickly
evidenc of axonal damage and bulb formation appears. Using this method a variety of brain areas were studied from 55 patients
who died within 24 h of a head injury. Immunocytochemical evidence of axonal injury was first detected after 2 h survival,
axonal bulbs were first identified after 3 h survival, and the amount of axonal damage and axonal bulb formation increased
the longer the survival time.
Received: 8 February 1996 / Revised, accepted: 13 May 1996 |
| |
| Keywords: | Head injury Axonal bulbs β -amyloid precursor protein (β -APP) Immunocytochemistry Diffuse axonal injury |
| 本文献已被 SpringerLink 等数据库收录！ |
|
