实时动态血糖监测系统在胰岛素泵强化治疗初发肥胖2型糖尿病患者低血糖规律中的应用

目的探讨实时动态血糖监测系统在胰岛素泵强化治疗初发肥胖2型糖尿病患者低血糖规律中的应用，以指导临床治疗和护理。方法573例住院初发肥胖2型糖尿病患者胰岛素泵强化治疗1周血糖稳定后，佩戴实时动态血糖监测系统72h，收集数据，进行分析，探讨胰岛素泵强化治疗初发肥胖2型糖尿病患者的低血糖规律。结果平均血糖与无症状低血糖、夜间低血糖发生率均呈双曲线负相关，餐后4h血糖与平均血糖呈直线正相关，晚餐后4h血糖值与夜间低血糖发生率呈指数曲线负相关。晚餐后4h血糖值4．5mmol／L时夜间低血糖发生率达50％以上。结论胰岛素泵强化治疗初发肥胖2型糖尿病患者的低血糖规律，可为胰岛素泵强化治疗而未佩戴实时动态血糖监测系统的初发肥胖2型糖尿病患者提供低血糖常见时段的参考，指导临床治疗和护理，具有重要的临床意义和社会经济效益。

Application of the regularity of hypoglycemia occurrence in the new-onset obese patients of type 2 diabetes accepting the insulin pump intensive therapy by continuous glucose monitors system

Objective To investigate the regularity of hypoglycemia occurrence in the obese patients with type 2 diabetes accepting the insulin pump intensive therapy by applying the continuous glucose monitors. Methods The blood sugar levels of the 573 new-onset obese inpatients with type 2 diabetes were the stable one week after accepting the insulin intensive therapy were studied by applying continuous glucose monitors. The data were collected and analyzed to probe the regularity of hypoglycemia occurrence. Results The average blood sugar level was negatively correlated with the incidence rate of symptomless hypoglycemia and nocturnal hypoglycemia respectively. The 4 hour postprandial blood sugar level was positively correlated with the average blood sugar level and negatively correlated to the incidence rate of nocturnal hypoglycemia. The incidence rate of nocturnal hypoglycemia exceeded 50 percent when the 4 hour postprandial blood sugar was under 4.5 mmol/L. Conclusions The research of regularity of hypoglycemia occurrence in the obese patients of type 2 diabetes accepting the insulin intensive therapy may provide the reference of common time of hypoglycemia occurrence in the patients accepting the intensive therapy. The study can provide good instructions for the clinical treatment and nursing care and had great clinical significance and societal economic benefits.