Atrial natriuretic peptide (ANP) in patients with chronic renal failure on maintenance haemodialysis

Atrial natriuretic peptide (ANP), a recently discovered cardiac hormone, is an important regulator of body fluid homeostasis. Twenty patients with established chronic renal failure and on maintenance haemodialysis were studied before and after dialysis with capillary dialysers. ANP was determined by RIA after extraction. Mean (±SD) pre-dialysis ANP concentration was 146±51 pg/ml and decreased significantly during dialysis to 68±38 pg/ml (p<0.001). Per cent and absolute changes in plasma ANP level correlated significantly with concomitant changes in body weight (r=0.764; p<0.001 and r=0.558; p<0.01, resp.) but not with changes in serum creatinine, blood pressure or serum electrolytes. The obtained results indicate that ANP levels in patients with chronic renal failure are elevated mainly due to fluid overload, and the rapid fall in ANP concentration observed during haemodialysis is caused by the removal of excess fluid from the body.