Apolipoprotein E polymorphisms and the risk of nonlesional temporal lobe epilepsy |
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Authors: | Gambardella A Aguglia U Cittadella R Romeo N Sibilia G LePiane E Messina D Manna I Oliveri R L Zappia M Quattrone A |
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Affiliation: | Institute of Neurology, School of Medicine of Catanzaro, Italy. neurol.unicz@interbusiness.it |
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Abstract: | PURPOSE: To evaluate whether the inheritance of the apolipoprotein E (ApoE) epsilon4 allele is a risk factor for nonlesional temporal lobe epilepsy (TLE), and to determine whether the newly described -491 A/T ApoE polymorphism may independently affect the risk of nonlesional TLE. METHODS: The study group consisted of 63 patients (35 women and 28 men; age at onset of epilepsy, 30.6 +/- 19.6 years; mean (+/-SD). All of them had received a diagnosis of nonlesional TLE after a detailed clinical, electroencephalographic, and brain magnetic resonance investigation. The ApoE polymorphisms were determined from blood samples by standard methods. The molecular study also was performed in 220 age- and sex-matched normal individuals. RESULTS: There were no differences between TLE patients and controls in either allelic or genotypic frequencies of the ApoE and -491A/T polymorphisms. Moreover, no effect of ApoE or -491A/T polymorphisms was found on the age at onset and severity of epilepsy. CONCLUSIONS: The allelic and genotypic frequencies of ApoE polymorphisms in Italian patients with nonlesional TLE are comparable to control values, indicating that ApoE polymorphisms are not a significant genetic risk factor for the occurrence of nonlesional TLE. |
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Keywords: | Apolipoprotein E Genetics Temporal lobe epilepsy |
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