持续气道正压通气治疗对OSAHS患者胰岛素抵抗的影响

目的观察持续气道正压通气（CPAP）治疗对阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者的胰岛素抵抗（IR）的影响,以验证OSAHS是否为引起患者IR增加的独立危险因素.方法选择60例OS-AHS患者,其呼吸暂停/低通气指数（AHI）为38.9±16.0;体重指数（BMI）为（27.1±2.5）kg/m2;经3个月的CPAP治疗,观察治疗前后反映IR的稳态模式评估（HOMA）指数变化.结果在BMI无明显改变的情况下,3个月的CPAP治疗后HOMA指数较治疗前明显降低（2.04±1.78 vs 3.53±2.76,P〈0.01）.结论 CPAP治疗可显著改善OSAHS患者的IR.

Efects of Continuous Positive Airway Pressure Treatment on Insulin Resistance in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

Objective To investigate the effects of continuous positive airway pressure（CPAP）treatment on insulin resistance in patients with obstructive sleep apnea hypopnea syndrome（OSAHS）.Methods Sixty patients with OSAHS were recruited.Their apnea hypopnea index（AHI）was 38.9±16.0,and BMI maintained at（27.1± 2.5）kg/m2.The homeostasis model assessment（HOMA）index was used to reflect IR and before and after 3 months＇ CPAP treatment.Results The HOMA index was significantly lower following 3 months＇ CPAP treatment than before treatment（2.04 ± 1.78 vs 3.53 ± 2.76,P 0.001）.Conclusion CPAP treatment can significantly improve IR in OSAHS patients,which suggests that OSAHS is an independent risk factor of IR.