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| ADAMTS-4在膝骨关节炎关节液中的表达和意义 | |
| 引用本文： | 邓紫玉,孙鹭,林俊,赵芳.ADAMTS-4在膝骨关节炎关节液中的表达和意义[J].昆明医学院学报,2011,32(6):59-61. |
| 作者姓名： | 邓紫玉 孙鹭 林俊 赵芳 |
| 作者单位： | 1. 昆明医学院附属昆华医院干部保健科,云南昆明,650032 2. 昆明医学院附属昆华医院检验科,云南昆明,650032 3. 昆明医学院附属昆华医院风湿免疫科,云南昆明,650032 |
| 基金项目： | 昆明医学院联合基金资助项目 |
| 摘 要： | 目的探讨ADAMTS-4在膝骨关节炎（OA）关节液中的表达和意义.方法单侧膝OA87例中,早期为45例,中晚期为42例.检测其患侧膝关节液中ADAMTS-4水平.以健康志愿者30例为正常对照组.应用酶联免疫吸附试验（ELISA）检测ADAMTS-4在关节液中的表达,以ELISA光密度（OD）值代表所测各项在关节液中的表达水平.结果膝OA患者关节液中ADAMTS-4表达水平均高于正常对照组（P〈0.05）;而正常对照组关节液中仅有少量聚蛋白多糖酶的表达.结论 ADAMTS-4水平在膝OA早期和中晚期关节液中均有高表达,检测关节液中ADAMTS-4表达水平有助于病情早期诊断. |
| 关 键 词： | 膝骨关节炎 关节液 聚蛋白多糖酶 |
Expression and Significance of ADAMTS-4 in Synovial Fluid of Knee Osteoarthritis |
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| DENG Zi-yu,SUN Yi,LIN Jun,ZHAO Fang.Expression and Significance of ADAMTS-4 in Synovial Fluid of Knee Osteoarthritis[J].Journal of Kunming Medical College,2011,32(6):59-61. | |
| Authors: | DENG Zi-yu SUN Yi LIN Jun ZHAO Fang |
| Institution: | DENG Zi-yu1),SUN Yi2),LIN Jun3),ZHAO Fang1)(1)Dept.of Geriatrics,2)Dept.of Laboratory,3)Dept.of Rheumatology and Immunology,The Affiliated Kunhua Hospital of Kunming Medical University,Kunming Yunnan 650032,China) |
| Abstract: | Objective To investigate expression and significance of ADAMTS-4 in synovial fluid of knee osteoarthritis.Method Among 87 patients with single-side knee osteoarthritis,45 of them suffered from early-stage knee osteoarthritis,and 42 of them from medium-later-stage knee osteoarthritis.The levels of ADAMTSs in synovial fluid of patitents were determined.30 healthy volunteers were selected into the control group.Results ADAMTSs-4 in synovial fluid had higher expression in the early stage OA group than in the la... |
| Keywords: | Knee osteoarthritis Synovial fluid ADAMTS-4 |
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