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Indirect 17(O)-magnetic resonance imaging of cerebral blood flow in the rat.
Authors:Dharmesh R Tailor  Arijit Roy  Ravinder R Regatte  Sridhar R Charagundla  Alan C McLaughlin  John S Leigh  Ravinder Reddy
Affiliation:Metabolic Magnetic Resonance Research and Computing Center, Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA. dtailor@mail.mmrrcc.upenn.edu
Abstract:Proton T(1rho)-dispersion MRI is demonstrated for indirect, in vivo detection of (17)O in the brain. This technique, which may be readily implemented on any clinical MRI scanner, is applied towards high-resolution, quantitative mapping of cerebral blood flow (CBF) in the rat by monitoring the clearance of (17)O-enriched water. Strategies are derived and employed for 1) quantitation of absolute H(2) (17)O tracer concentration from a ratio of high- and low-frequency spin-locked T(1rho) images, and 2) mapping CBF without having to transform the T(1rho) signal to H(2) (17)O tracer concentration. Absolute regional blood flow was mapped in a single 3-mm brain slice at an in-plane resolution of 0.4 x 0.8 mm within a 5-min tracer washout time; these data are consistent with the less localized CBF measurements reported in the literature. T(1rho)-weighted imaging yields excellent signal-to-noise ratios, spatiotemporal resolution, and anatomical contrast for mapping CBF.
Keywords:T1ρ‐dispersion imaging  H217O  cerebral blood flow  brain mapping
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