The role of diabetes mellitus in the aetiology of renal cell cancer |
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Authors: | P Lindblad W H Chow J Chan A Bergström A Wolk G Gridley J K McLaughlin O Nyrén H O Adami |
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Institution: | (1) Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden, SE;(2) National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, USA, US;(3) Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA, US;(4) International Epidemiology Institute, Rockville, Maryland, USA, US |
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Abstract: | Summary To investigate the relation between diabetes mellitus and the risk of renal cell cancer we carried out a population-based
retrospective cohort study. Patients identified in the Swedish Inpatient Register who were discharged from hospitals with
a diagnosis of diabetes mellitus between 1965 and 1983 formed a cohort of 153 852 patients (80 005 women and 73 847 men).
The cohort members were followed up to 1989 by record linkage to three nation-wide registries. Standardized incidence ratios
(SIRs) and standardized mortality ratios (SMRs) were computed using age-specific sex-specific and period-specific incidence
and mortality rates derived from the entire Swedish population. After exclusion of the first year of observation, a total
of 267 incidences of renal cell cancer (ICD-7 : 180.0) occurred in diabetic patients compared with the 182.4 that had been
expected. Increased risks were observed in both women (SIR = 1.7, 95 % confidence interval, CI = 1.4–2.0) and men (SIR = 1.3;
95 % CI = 1.1–1.6) throughout the duration of follow-up (1–25 years). A higher risk was seen for kidney cancer (ICD-7 : 180)
mortality (SMR = 1.9; 95 % CI = 1.7–2.2, women; SMR 1.7, 95 % CI = 1.4–1.9, men). In comparison with the general population,
patients with diabetes mellitus have an increased risk of renal cell cancer. Diabetologia (1999) 42: 107–112]
Received: 12 December 1997 and in final revised form: 25 August 1998 |
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Keywords: | Kidney neoplasms diabetes mellitus cohort study risk factors Sweden |
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