| 肾衰保肾胶囊延缓腺嘌呤致大鼠慢性肾功能衰竭的实验研究 |
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| 引用本文： | 张佩青,LIU Li,刘锂,乔会秀. 肾衰保肾胶囊延缓腺嘌呤致大鼠慢性肾功能衰竭的实验研究[J]. 中医药学报, 2007, 35(1): 22-24 |
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| 作者姓名： | 张佩青 LIU Li 刘锂 乔会秀 |
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| 作者单位： | 1. 黑龙江省中医研究院,黑龙江,哈尔滨,150036
2. 黑龙江中医药大学,黑龙江,哈尔滨,150040 |
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| 基金项目： | 黑龙江省中医药管理局科研基金 |
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| 摘 要： | 目的：探讨中药方剂肾衰保肾胶囊对腺嘌呤致慢性肾功能衰竭（CRF）大鼠肾功能的影响。方法：通过灌服腺嘌呤建立大鼠慢性肾衰模型，检测各组大鼠血浆BUN，Scr的变化，肾组织纵切后做HE、Masson染色，在光学显微镜下观察肾脏病理改变与肾纤维化情况。结果：肾衰保肾胶囊能够显著改善腺嘌呤致CRF大鼠的肾功恶化（P〈0．01），降低蛋白尿（P〈0．01），有效延缓慢性肾衰竭的进展。
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| 关 键 词： | 慢性肾衰竭 腺嘌呤 肾衰保肾胶囊 实验研究 |
| 文章编号： | 1002-2392（2007）01-0022-03 |
| 修稿时间： | 2006-11-232006-12-10 |
Experimental study of Shenshuai Baoshen Capsule on myocardial mitochondrion injury in mice |
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| LIU Li. Experimental study of Shenshuai Baoshen Capsule on myocardial mitochondrion injury in mice[J]. Acta Chinese Medicine and Pharmacology, 2007, 35(1): 22-24 |
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| Authors: | LIU Li |
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| Abstract: | Objective: To investigate the curative effect of Chinese medicinal formula: Shenshuai Baoshen Capsule on chronic renal failure of rats induced by adenine.Method: The rat model of chronic renal failure was induced by gastric infusion of adenine.The changes of BUN and Scr in rat blood serum were analyzed,and the renal pathological changes and the fibrosis of kidney organization were measured by observing the slices of kidney organization that stained by HE and Masson.Results: Shenshuai Baoshen Capsule could significantly improve the aggravation of renal function induced by adenine(P<0.01),reduce albuminuria(P<0.01) and effectively postpone the development of chronic renal failure. |
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| Keywords: | chronic renal failure Chinese medicine therapy adenine Shenshuai Baoshen Capsule |
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