Influence of microcystin-YR and nodularin on the activity of some proteolytic enzymes in mouse liver. |
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| Authors: | A Lankoff A Kolataj |
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| Institution: | Department of Radiobiology and Immunology, Pedagogical University, Kielce, Swietokrzyska, Poland. alankoff@pu.kielce.pl |
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| Abstract: | The activity of cathepsins D and L, arginine aminopeptidase, dipeptidase II and dipeptidase IV was determined in the lysosomal, microsomal, cytoplasmatic fractions and in the complete homogenate of the mouse hepatocytes following injection of microcystin-YR and nodularin. The effect of both toxins depended on the time of action and on the fraction of cell cytoplasm. Microcystin-YR inhibited the synthesis of the studied proteases and caused a labialization of lysosomal membranes, whereas nodularin induced the synthesis of the enzymes and destabilized the reticulum endoplasmatic membranes. |
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