| 神效散巴布剂的体外透皮吸收研究 |
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| 引用本文： | 王爱国,谷福顺,郑昆仑,陆军,赵允,王晓辉. 神效散巴布剂的体外透皮吸收研究[J]. 现代药物与临床, 2021, 36(9): 1812-1816 |
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| 作者姓名： | 王爱国 谷福顺 郑昆仑 陆军 赵允 王晓辉 |
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| 作者单位： | 天津市中医药研究院附属医院,天津 300120;天津中医药大学第二附属医院,天津 300250;天津市医药科学研究所,天津 300020 |
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| 基金项目： | 天津市中医药重点领域科研项目（2017007）;天津市中医药研究院附属医院院内科研基金资助项目（2020004） |
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| 摘 要： | 目的 比较神效散散剂和巴布剂的透皮吸收效果.方法 采用HPLC法测定神效散散剂和巴布剂中血竭素、三七皂苷R1.使用扩散池装置,以离体小鼠皮肤为屏障进行体外透皮吸收研究,比较神效散巴布剂和散剂中血竭素、三七皂苷R1的累积渗透量、渗透速率.结果 神效散散剂和巴布剂中血竭素、三七皂苷R1累积渗透量随着时间的增加而增大,且两种...
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| 关 键 词： | 神效散巴布剂 神效散 血竭素 三七皂苷R1 累积渗透量 渗透速率 高效液相色谱 |
| 收稿时间： | 2021-02-07 |
Transdermal absorption of Shenxiao Powder Cataplasm |
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| WANG Ai-guo,GU Fu-shun,ZHENG Kun-lun,LU Jun,ZHAO Yun,WANG Xiao-hui. Transdermal absorption of Shenxiao Powder Cataplasm[J]. Drugs & Clinic, 2021, 36(9): 1812-1816 |
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| Authors: | WANG Ai-guo GU Fu-shun ZHENG Kun-lun LU Jun ZHAO Yun WANG Xiao-hui |
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| Affiliation: | Affiliated Hospital of Tianjin Academy of TCM, Tianjin 300120, China;Second Affiliated Hospital of Tianjin University of TCM, Tianjin 300250, China; Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, China |
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| Abstract: | Objective To evaluate the transdermal absorption effect of Shenxiao Powder Cataplasm. Methods Dracorhodin and notoginseng saponin R1 in Shenxiao Powder Cataplasm and Shenxiao Powder were determined. Diffusion cell device was used, and in vitro transdermal absorption was studies with isolated mouse skin as a barrier. The cumulative penetration and penetration rate of dracorhodin and notoginseng saponin R1 in Shenxiao Powder Cataplasm and Shenxiao Powder were compared. Results The cumulative penetration of the two dosage forms were increased with the increase of time, and the cumulative penetration of the two main components was:cataplasm > powder; Penetration rate:cataplasm > powder. Conclusion Compared with Shenxiao Powder, Shenxiao Powder Cataplasm has stronger transdermal absorption. |
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| Keywords: | Shenxiao Powder Cataplasm Shenxiao Powder dracorhodin notoginseng saponin R1 cumulative penetration penetration rate HPLC |
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