西吡氯铵含漱液联合丁硼乳膏治疗智齿冠周炎的临床疗效及对炎症介质的影响

目的 探讨西吡氯铵含漱液联合丁硼乳膏治疗智齿冠周炎的临床疗效及对炎症介质的影响.方法 回顾性分析2020年2月—2021年2月在延安市人民医院治疗的216例智齿冠周炎患者的临床资料,根据用药的差别分为对照组和治疗组,每组各108例.对照组给予丁硼乳膏,取1 g药物涂抹于患处,滞留3～5 min后用清水漱口洗去,3次/d...

Clinical efficacy of cetylpyridinium chloride gargle combined with butylborone cream in treatment of pericoronitis of wisdom teeth and its effect on inflammatory mediators

Objective To investigate the clinical effect of cetylpyridinium chloride gargle combined with butylborone cream in treatment of pericoronitis of wisdom teeth and its effect on inflammatory mediators. Methods The clinical data of 216 patients with pericoronitis of wisdom teeth in Yan''an People''s Hospital from February 2020 to February 2021were analyzed retrospectively and divided into control and treatment groups based on different treatments, and each group had 108 cases. Patients in the control group were administered with Dingpeng Emulsion, applied 1 g medicine to the affected area, rinsed with clean water after staying for 3-5 min, three times daily. Patients in the treatment group were gargled with Cetylpyridinium Chloride Gargle, 15 mL/time, gargled forcefully for 1 min, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, the VAS, MDAS, symptom scores, periodontal pocket probing depth, plaque index, periodontal attachment level, gingival sulcus bleeding index, and the levels of CRP, PGE₂, IL-6 and TIMP-1 in gingival crevicular fluid in two groups before and after treatment were compared. Results After treatment, the clinical effective rate in the control group was significantly lower than that in the treatment group (85.19% vs 99.07%, P<0.05). After treatment, the VAS score, MDAS score and symptom score in two groups were significantly decreased (P<0.05), and the treatment group decreased more significantly (P<0.05). After treatment, the probing depth of periodontal pocket, plaque index, periodontal attachment and gingival sulcus bleeding index were significantly decreased in two groups (P<0.05), and these indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the levels of CRP, PGE₂, IL-6, and TIMP-1 in gingival crevicular in two groups fluid decreased significantly (P<0.05), especially in the treatment group (P<0.05). Conclusion Cetylpyridinium Chloride Gargle combined with Dingpeng Emulsion in treatment of pericoronitis of wisdom teeth can effectively improve the symptoms of the patients, reduce the inflammatory reaction and improve the periodontal condition, which has a certain clinical application value.