Local Disodium Cromoglycate Is Ineffective in Ulcerative Proctosigmoiditis |
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Authors: | NILS HOVDENAK,LARS HALVORSEN,K RE NORDG RD,HENNING SCHJ
NSBY,HELGE SIGSTAD |
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Affiliation: | NILS HOVDENAK,LARS HALVORSEN,KÅRE NORDGÅRD,HENNING SCHJØNSBY,HELGE SIGSTAD |
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Abstract: | ABSTRACT. Conflicting results have emerged from studies using oral and rectal disodium cromoglycate (DSCG) in inflammatory bowel disease. In the present double-blind study, 43 patients with active ulcerative proctosigmoiditis received either placebo (n=22) or 600 mg DSCG (n= 21) rectally as enemas for eight weeks. Assessment was made from clinical investigations, endoscopy, laboratory tests, biopsies, and diary cards. No statistically significant differences in bowel frequency, rectal bleeding, general well-being, abdominal pain, and severity and extent of the disease were found between the groups during the study. There was no significant change in the histologic parameters. No side-effect was encountered. It is concluded that DSCG did not improve symptoms or inflammatory changes in ulcerative proctosigmoiditis. |
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Keywords: | ulcerative colitis disodium cromoglycate |
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